Full list of Antidotes discussed in this article.

An antidote is a drug designed to counteract the effects of toxicity of another drug, poison or toxin. This toxicity usually arise from either intentional or unintentional overdose or when the body system like the kidneys or liver is impaired to excrete these drugs even when taken in the right dose.

I hope this helps you as this compilation of antidotes below is straight to the point.


📍Activated charcoal with sorbitol
Used for many oral toxins

📍Theophylline or Caffeine
Adenosine receptor agonist poisoning

📍Antimuscarinic drugs (e.g. atropine)
Organophosphate and carbamate insecticides
Nerve agents
Some poison mushrooms

📍Beta blockers

📍Calcium chloride
Calcium channel blocker toxicity
Black widow spider bites.

Activated charcoal is the most popular of all antidotes

📍Calcium gluconate
Calcium channel blocker toxicity
Hydrofluoric acid burns

📍Chelators such as EDTA, dimercaprol (BAL), penicillamine, and 2,3-dimercaptosuccinic acid (DMSA, succimer)
Heavy metal poisoning

📍Cyanide antidotes (hydroxocobalamin, amyl nitrite, sodium nitrite, or thiosulfate)
Cyanide poisoning

Serotonin syndrome

📍Deferoxamine mesylate
Iron poisoning

📍Digoxin Immune Fab antibody (Digibind and Digifab)
Digoxin poisoning

📍Diphenhydramine hydrochloride and benztropine mesylate
Extrapyramidal reactions associated with antipsychotics

📍100% Ethanol or Fomepizole
Ethylene glycol poisoning and methanol poisoning

Benzodiazepine overdose

📍100% oxygen or hyperbaric oxygen therapy (HBOT)
Carbon monoxide poisoning and cyanide poisoning

Dabigatran etexilate

📍Andexanet alfa
Reversal of factor Xa inhibitors, rivaroxaban and apixaban

📍Insulin + Glucagon
Beta blocker poisoning or calcium channel blocker poisoning

Methotrexate, trimethoprim and pyrimethamine overdose

Local anesthetic toxicity

📍Methylene blue
Treatment of conditions that cause methemoglobinemia

📍Naloxone hydrochloride
Opioid overdose

Acetaminophen (paracetamol) poisoning

Oral hypoglycemic agents

📍Pralidoxime chloride (2-PAM)
When given with atropine: organophosphate insecticides, nerve agents, some poison mushrooms

📍Protamine sulfate
Heparin poisoning

📍Prussian blue
Thallium poisoning

📍Physostigmine sulfate
Anticholinergic poisoning

Isoniazid poisoning

📍Phytomenadione (vitamin K) and fresh frozen plasma
Warfarin overdose

📍Sodium bicarbonate

📍I.V Silibinin
Amatoxin ingestion

📍Succimer (dimercaptosuccinic acid, DMSA)
Lead poisoning



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