Amatem soft gel Forte side effects, Uses, composition, effectiveness, indication, contraindication, dosage for adults and children , and price.
AMATEM SOFT GEL FORTE
(Artemether 80mg + Lumefantrine 480mg)
Composition: Amatem soft gel ingredients
Each soft Gelatin Capsule contains;
Artemether ph. Int. 80mg
Lumefantrine ph. Int. 480mg
Clinical uses of amatem soft gel
1. To treat malaria
2. To treat chloroquine resistant malaria
3. In cases malaria treatment failure especially with chloroquine, amatem forte may be the new drug of choice.
Please note that there are fake amatem soft gel in the market, and fake amatem will not give you the desired result aa it will not clear the malaria parasite in your blood. Always make sure you buy from trusted pharmacies that you know stock original amatem soft gel. Beware of fake and adulterated amatem soft gel. To get original amatem, always look out for the code on the packet.
Mechanism of Action :
Amatem soft gel forte contains Artemether and Lumefantrine whose combination is a fixed dose aretemisinin-based combination therapy (ACT) combining artemether, an artemisinin derivative and lumefantrine, a synthetic antimalarial drug.
Artemether is adsorbed with peak plasma concentration reached about 2 hours after dosing. Absorption of lumefantrine, a highly lipophilic compound about 6 to 8 hours after administration. Artemether and lumefantrine are both highly bound to human serum protein in vitro (95.4% and 99.7%, respectively).
Artemether are cleared from plasma with an elimination half-life of about 2 hours.
Lumefantrine is eliminated more slowly, with a terminal half-life of 3-6 days.
No specific pharmacokinetic studies have been performed in patients older than 65 years of age.
How to take Amatem soft gel forte
Dosage in Adult parents (>16 years of age)
A 3-day treatment schedule with a total of 6 doses is recommended for adult patients with a bodyweight of 35 kg and above:
Take One capsule as an initial dose, 1 capsule again after 8 hours and then 1 capsule twice daily (morning and evening) for the following two days (total course of 6 capsules).
DO NOT EXCEED THE DOSAGE PRESCRIBED
Weight in Kgs: 35kg- above
Total capsules : 6
0 Hours 8 Hours
(Initial dose) (after dose)
1 capsule. 1 capsule.
24 Hours 36 Hours
1 capsule. 1 capsule.
48 Hours 60 Hour
1 capsule. 1 capsule.
For the treatment of most forms and resistant type of malaria.
CONTRAINDICATIONS TO AMATEM SOFT GEL
– Hypersensitivity to any of the ingredients.
– Patients who are taking any drug which is metabolised by the cytochrome enzyme CYP2D6 (e.g. flecainide, metoprolol, imipramine, amitryptyline, clomipramine).
– Patients with disturbances of electrolyte balance eg hypokalemia.
Amatem soft gel Forte side effects
Common side effects may include:
👉Palpitations/fast heart beat
👉Diarrhoea (runny stomach)
👉Insomnia (poor sleep)
👉Hallucinations or nightmares in some persons as reported.
👉fever, cough, feeling weak or tired;
👉muscle pain (myalgia), tenderness, or weakness;
👉joint pain (arthralgia);
👉vomiting, nausea; or
👉loss of appetite(anorexia).
👉Change in colour of urine
👉Allergies which could be severe and life threatening.
SPECIAL PRECAUTIONS AND WARNING FOR USE
– Amatem must not be used in first Trimester of Pregnancy.
– It has not been evaluated for treatment of severe malaria. Amatem is not really that effective in the treatment of severe malaria.
– For the treatment of most forms and resistant type of malaria.
It has the interactions with other antimalarials, CYP450 3A4 Inhibitors, Protease Inhibitor and anti-retroviral drugs.
Amatem soft gel in pregnancy and breastfeeding mothers.
There is insufficient data from the use of amatem soft gel forte (artemether and lumefantrine) in pregnant women.
Based on animal data, it is suspected to cause serious birth defects when administered during first trimester of Pregnancy.
During the second and third trimester, treatment should only be considered if the expected benefits to the mother outweighs the risk to the foetus.
Can a nursing mother take amatem soft gel? Animal data suggest excretion into breast milk but no data are available in humans. Women taking amatem should not breastfeed during their treatment.
Due to the long elimination half-life of lumefantrine (4 to 6 days), it is recommended that breastfeeding should not resume until at least one week after the last dose unless potential benefits to the mother and child outweigh the risks of treatment.
In case of suspected overdosage symptomatic and supportive therapy should be given as appropriate which including ECG and blood potassium monitoring.
Can amatem soft gel cause miscarriage?
No. Amatem is a safe drug in the second trimester of pregnancy and do not cause miscarriage.
Can an ulcer patient take Amatem soft gel?
Yes you can…Amatem does not cause ulcer or worsen ulcer. Amatem is safe in in ulcer patients.
Can a pregnant woman take amatem soft gel in third trimester?
Yes. Amatem soft gel is contra-indicated in the first trimester but it is safe in the second and third trimester.
Can a nursing mother take Amatem soft gel?
Yes. Amatem is safe in nursing or breastfeeding mothers.
Amatem malaria drug price in Nigeria is between #1,800 – #2,000 naira depending on the location and pharmacy.
Store below 25°C in cool & dry place.
Blister packs of 1×6 soft gelatin capsule.
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I became so worried when I saw my urine looking very dark in colour. Can I continue with my remaining dose?
Been purging(watery stool) since i started using the medication and it has never happened like that before, I’m on my fourth dose now, Should I continue using it or I should stop?
Continue and finish the dose. Also take ors for the diarrhoea
Can someone who has arrhythmia take this drug?
Yes…but discuss with your doctor
4months breast feeding can take Amatem softgel?
The amartem soft gel was talking by one of my friends, he not walk to bathroom to urinate in the night due to body weakness. We almost rush him that night, is it not better to stop it?
Probably something else caused that
6month pregnancy can take amatam softgel
I mistakenly took 2 tablet at once, I hope everything will be fine cos am worried sick
Safe…but don’t make that mistake again
I mistakenly took 2 Amatem soft gel at once, I hope I will be fine cos am worried sick
I’m 19 weeks pregnant, did malaria test and the results says 1+ nurse recommend amatem is this okay and safe?
No. Fansidar is safer
Good morning Mr. Udomoh thanks for your response
But I have started using it and have just 2 capsule left for this evening and tomorrow morning. Do you advice I stop???
I have blister on my lips Can it heal it because of the fever
See a doctor
Pls Sir I’m 21week pregnant can I take Armathem soft gel or can u prescribe something else for me
The Amatem that’s in 24 capsules, is it for children?
Am breastfeeding a 4 month old baby, I just finish d last dose of amatem soft gel but I realize is making my baby to be very weak and crying through out
Not because of the amatem madam….your baby may have other reasons for the weakness and cry…
Please sir, i just finished taking amartem and notice thesame allergy (itchy rashes) on my hands and on my baby’s feet. could it be the drugs?
Dr udomoh, I am thirteen week pregnant and Amatem soft gel was recommended by a doctor, is it ok to take it. Am on it now , should I stop it . Can it affect the baby
It is OK and safe