Silbecor Cream: Uses, Indications, Composition, Dosage, Side Effects & Price
What is Silbecor Cream used for?
SILBECOR CREAM
SILVER SULFADIAZINE 1% W/W
COMPOSITION
Each 1gm contains:
Silver sulfadiazine USP………..10mg
PHARMACODYNAMIC PROPERTIES
Silver sulphadiazine inhibits the growth in-vitro of pathogenic bacteria and fungi.Not all strains of a particular organism may be susceptible.Silver is released slowly from the preparation in concentrations that are selectively toxic to micro-organisms.Bacteria may develop resistance to silver sulphadiazine.
PHARMACOKINETIC PROPERTIES
Sulphadiazine is slowly released by silver sulphadiazine when I’m contact with wound exudates.Up to 10% of the sulfadiazine may be absorbed.Blood concentrations of 10 to 20 micrograms/ml have been reported although higher concentrations may be achieved she is extensive areas of the body are treated. There is possibility that some silver may also be absorbed.
What is Silbecor Cream used for?
INDICATIONS
Silbercor is used topically for the short term treatment of minor burns.
Sibecor cream is helpful in the soothing of sunburns
Sibecor #cream is good in clearing face pimples infected by bacteria.
Sibecor cream does not cure eczema as claimed
You can use sibecor cream to dress open wounds
CONTRAINDICATIONS
Hypersensitivity to sulphonamide.
Sulphonamide therapy is known to increase the possibility of kernicterus.
Silbecor cream should therefore not be used in pregnant women,premature infants or infants during the first months of life.
Lactation (refers to “ pregnancy and lactation”).
Silbecor should not be used if hepatic or renal function becomes impaired porphyria
WARNINGS AND SPECIAL PRECAUTIONS
For external use only
Patient hypersensitive to sulphonamides,furosemide,thiazide diuretics,sulphonylureas or carbonic anhydrase inhibitors May be sensitive to silbecor.
A fall in white blood cell count has been demonstrated (refer to “side effects “)
Appreciable amounts of sulphadiazine may be absorbed to produce systemic side effects,when silbecor is applied to a large area and when the lesion(s) is/are deep.
Systemic absorption of silver,resulting the argyria,with discoloration of the skin and sensorimotor neuropathy, can occur when silbecor is applied to large area wounds or over prolonged periods.
Local skin sensitivity to silbecor may occur, especially when exposed to sunlight. Treatment should be discontinued if a rash appears because of the danger of a severe allergic reaction (Stevens-Johnson syndrome)(refer to “side effects”).
Sulphadiazine may displace serum bound bilirubin resulting in jaundice and kernicterus in premature neonates.
Eiderly patients and patients with aids may be particularly prone to the adverse reactions. The risk of crystallisation in the urine may be reduced with the administration of fluids to maintain high urine output.
Adequate fluid intake and normalisation of acid base balance is important( refers to “side effects “).
INTERACTION
Silbecor may potentials the effect of the following medicine:
. Oral anticoagulants
. Methotrexate
. Phenytoin.
High doses of silbecor can have a hypoglycemia effect;the anti diabetics effect of the sulfonylurea compounds may be enhanced by silbecor. The silver content of silbecor May inactivate enzymatic debriding agents. Concurrent use with cimetidine May increase the incidence of leukopenia (refer to “side effects “)
PREGNANCY AND LACTATION
Silbecor is contraindicated during pregnancy and lactation (refer to “contraindications “)
DOSAGE AND DIRECTIONS FOR USE
Silbecor should be applied daily in a layer approximately 3-5mm thick with a sterile gloves hand or spatula. The wound may be dressed or left open.one container of silbecor should be reserved for one patient and any remaining cream should be discarded on completion of treatment.
SIDE EFFECTS
Blood and lymphatic system disorders less frequent: These effects are through to be hypersensitivity effects:
. Agranulocytosis
. Aplastic anaemia
. Thrombocytopenia
. Leukopenia
. Hypo prothrombinaemia
. Eosinophilia
ENDOCRINE DISORDERLY
Frequent:Hypoglycemia.
Frequent unknown:hypothyroidism.
NERVOUS SYSTEM DISORDERS
Frequency unknown: aseptic meningitis;ataxia;benign intracranial hypertension;convulsions;dizziness;drowsiness;fatigue;headache;insomnia;mental depression;peripheral or optic neuropathies;psychoses; vertigo.
GASTROINTESTINAL DISORDERS
Frequent:nausea;vomiting;anorexia;diarrhea.
HEPATO-BILIARY DISORDERS
Frequent unknown:jaundice;kernicterus in premature neonates
SKIN AND SUBCUTANEOUS TISSUE DISORDER
Frequent:rashes;photosensitive reaction;exfoliating dermatitis; dermatitis;erythema nodosum.
Frequency unknown:toxic epidermal necrolysis; Stevens-Johnson syndrome;systemic lupus erythematosus.
RENAL AND URINARY DISORDERS
Frequent:nephrotoxic reactions( including interstitial nephritis and tubular necrosis);lumbar pain, haematuria,Oliguria and anuria May also occur due to crystallisation in the urine.
GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS
Frequent:fever.
Less frequent:local pain and irritation;fungal invasion of wound;anaphylaxis
Frequency unknown: generalised hypersensitivity effect include:
. Syndrome resembling serum sickness
. Liver necrosis
. Hepatomegaly,jaundice and myocarditis
. Pancreatitis
. Pulmonary eosinophilia
. Fibrosing alveolitis
. Vasculitis including polyarthritis nodosa.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
See “side effects”. Treatment is symptomatic and supportive.
PRICE;
The price of sibecor cream is about N500 naira per 50g tube.
IDENTIFICATION
Odourless,white homogeneous cream.
PRESENTATION
50g printed aluminum tube
STORAGE:
store below 3.c
Protect from light. Keep out of reach of children.
For external use only
