Parkinson’s Drugs: Parkinson’s medications list including newer drugs
PARKINSON’S DISEASE DRUGS
👉 often taken in combination with other drugs, such as carbidopa and entacapone.
🟤 DOPA-DECARBOXYLASE INHIBITORS
Drugs that prevent peripheral conversion of levodopa to dopamine.
🟢 DOPAMINE AGONISTS
🟡 MAO-B INHIBITORS
⚫️ COMT INHIBITORS
👉 pimavanserin (psychosis associated with PD)
Newer anti-parkinsonism drugs;
1. Artemisinin shows promise in treating Parkinson’s disease
A new study suggests that artemisinin, a compound derived from the wormwood plant, may be a promising new treatment for #Parkinson’s #disease. Artemisinin is best known for its antimalarial properties, but it also has anti-inflammatory and neuroprotective effects.
In the study, researchers found that artemisinin treatment improved motor symptoms and protected dopamine #neurons in a #mouse model of Parkinson’s disease. Artemisinin also inhibited a signaling pathway thought to play a role in the #inflammation and neurodegeneration that occurs in Parkinson’s disease.
These results are very exciting because they suggest that artemisinin may be a potential new treatment for Parkinson’s disease. However, #clinicaltrials are needed to test the effects of artemisinin in people with Parkinson’s disease.
a combination of levodopa and carbidopa, is primarily used in the management of Parkinson’s disease. Levodopa is converted to dopamine in the brain, compensating for the deficiency associated with Parkinson’s.
– Parkinson’s Disease
– Levodopa Conversion: Levodopa is a precursor of dopamine, a neurotransmitter crucial for motor control. Once in the brain, levodopa is converted to dopamine, alleviating Parkinson’s symptoms.
– Carbidopa Inhibition: Carbidopa is often combined with levodopa to prevent its conversion to dopamine outside the brain, ensuring more levodopa reaches the brain and minimizing side effects.
Adults— At first, 25 milligrams (mg) carbidopa and 100 mg levodopa (1 tablet) 3 times a day. May Increase Later
– Nausea and Vomiting: Common side effects, especially at the initiation of treatment.
– Dyskinesias: Involuntary movements may occur, especially with long-term use.
– Orthostatic Hypotension: A sudden drop in blood pressure upon standing.
– Psychiatric Effects: Behavioral changes, hallucinations, or confusion may occur.
Carbidopa and levodopa have been found to cause vitamin B6 deficiency. Patients on carbidopa/levodopa should be on prophylactic vitamin B6.
Reference: Lv J, et al. CNS Neurosci Ther. 2023;29(4):1012-1023. doi:10.1111/cns.14063