Sayana Press Vs Depo-Provera: What is the difference between Sayana Press and Depo-Provera?

I know it will surely get to a time when I will have to compare and contrast the differences and similarities between the injectible contraceptives – depo provera and sayana press…

I am going to look at the differences between Sayana Press and depo-provera under the following headers.

Active agent

Both depo-provera and sayana press have Medroxyprogesterone acetate (DMPA) as active ingredient…DMPA is a progestin analog. This means both depo provera and sayana #press are progestin only birth control injectibles. Sayana press contains 104mg of DMPA while depo-provera call contains a higher amount of progesterone, it contains 150mg of DMPA.


Sayana press and depo provera are both hormonal contraceptive used to prevent pregnancy lasting for 3 months. Depo provera can be also used as hormonal therapy for post-menopausal women… Women that have attained menopause do take depo shots.


Pfizer, a big pharmaceutical company in the United States manufactures both sayana press and depo provera.. Sayana press has some added advantage you will see later in the article…but they are not really different when you look at both critically.

Duration of action

Depo provera will prevent pregnancy for 12 weeks (3months) while sayana press prevent pregnancy for 13 weeks (an extra one week advantage added)…However, both sayana press and depo provera are still 3 monthly contraceptives.

Sayana Press Vs Depo-Provera: What is the difference between Sayana Press and Depo-Provera?
Depo-provera vs Sayana Press

Route of administration

They are both injectibles quite alright. However, Depo provera is given intramuscularly (deep into your muscle) on your thigh, arm (deltoid) or buttocks while sayana press is given subcutaneously(under your skin)…You will feel slight pain on the injection site during and even after the administration but it will resolve.When it comes to more and route of administration, sayana press has an added advantage that depo provera lacks…

Sayana press can be self administered by the woman (if taught) and this makes its use at home possible and less embarrassing. Just go to the pharmacy, buy sayana press and administer it under the skin yourself. No stress.

Side effects

Both sayana press and depo-provera have same side effects because they both have DMPA as active agents with same mechanism of action. Side effects like vaginal bleeding, delay in periods, weight gain, headaches, bloating, dizziness, delay in achieving pregnancy after discontinuing use etc are done documented side effects of both #sayana #press and #depo-provera.

How long does it take to get pregnant after taking depo provera or sayana press…?

It takes about 4 months to 1 year to take in after using either if the injectible contraceptives…it can even take as long as 2 years.


Both sayana press and depo-provera are quite affordable and readily available in the pharmacies…

Learn more about birth control here.

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