Silybon 70/140: Uses, Composition, Dosage, Side Effects, indications , CONTRAINDICATIONS and Price.
Silybon – 70/140 Silymarin Tablets
COMPOSITION OF SILYBON:
Each film coated tablet contains:
Silybon – 70 : silymarin ( as silybin) 70 mg
Silybon-140: silymarin ( as silybin) 140mg
EXCIPIENTS: microcrystalline cellulose, Dicalcium phosphate anhydrous, colloidal silicon Dioxide, methyl paraben, propyl paraben, maize starch, microcrystalline cellulose, sodium starch Glycollate, purified talc, magnesium stearate and purified water.
CHEMISTRY:
silymarin is obtained from silybum marianum (milk thistle fruit).The plant grows widely over Europe and Asia including India. Silymarin contains three main components (flavonolignans) namely silybin, silycristin and silydianin. Chemically it is 7,8- dihydroxyflavone.
PHARMACOLOGY:
Silymarin, the active principle of the fruit of silybum marianum, acts as a cell membrane stabilizer and protects the liver against deleterious agents.
Silymarin directs action to liver cells, protects its membrane integrity, stabilizes and strengthens membranes of cell organs and nuclei in the cell to prevent mutation and death of the cells by toxic substances thus increasing liver function.
Silymarin can also enhance the metabolic function of liver cell, repair damaged liver cell, accelerate rebirth of liver cell, prevent fatty acid change of liver cell caused by alcohol, reduced glycogen content and mitochondrial alteration.
Pharmacokinetics:
silymarin is readily absorbed from the gastrointestinal tract. In animals and humans, peak plasma levels are reached in four to six hours after an oral dose. Silymarin undergoes significant hepatic metabolism. Silymarin is excreted primarily via the bile but some clearance is also achieved via the kidneys. The clearance half- life of silymarin is six to eight hours.
INDICATIONS AND USAGE:
silymarin is useful in the treatment of:
– Infective hepatitis
– Alcoholic liver disease
– Toxic metabolic Liver damages (e.g. fatty infiltration of liver), mushroom poisoning, carbon tetrachloride poisoning.
Can silybon cure hepatitis B?
No. Silybon cannot cure hepatitis B or hepatitis C. Silybon will only help to heal your injured liver occasioned by hepatitis B or C.
Can silybon cure fatty liver?
Alcohol, smoking and obesity causes fatty liver disease. Reduce weight, stop smoking and stop alcohol to treat your fatty liver. Silybon will help heal the injured liver occasioned by fatty liver.
Silybon 140 alternative/Substitute: Livorlin Forte, Udiliv 300, Liver Aid, Hepatek etc
CONTRAINDICATIONS:
Silybon 70mg is contraindicated in patients hypersensitive to silymarin or any other ingredient. In rare instances, a laxative effect may occur due to increased liver function
SIDE EFFECTS / ADVERSE REACTIONS:
silymarin is reported to have a very good safety profile. Both animal and human studies shows that silymarin is non- toxic even given at high doses (>1500mg/day).
However, a laxative effect is noted at the prescribed dose, which may be due to increased bile secretion and bile flow. Other commonly noted adverse effects are : bloating, dyspepsia, nausea and irregular stools.
Silymarin may also cause an allergic reaction in some individuals, particularly those with known allergies to plants of Asteraceae family ( thistles, daisies, artichokes). No other widely reported side effects are known when silymarin is taken in proper therapeutic dosages.
PRECAUTION / WARNINGS:
In theory, silymarin may lower blood sugar levels. Caution is advised in patients with diabetes or hypoglycemia, and in those taking drugs that affect blood sugar . serum glucose levels may need to be monitored.
PREGNANCY AND LACTATION:
There are currently no adequate and well – controlled trials with silymarin in pregnant and lactating women. Silymarin should be used only after detailed analysis of risk and benefit ratio.
DRUG INTERACTION :
No drug interaction has been reported with other drugs.
DOSAGE OF SILYBON 70 :
The usual recommended dose of silymarin is 70mg, three times a day, in mild to moderate cases. In severe cases 140 mg three times a day. Depending on the grade and severity of the liver disease 4 weeks treatment is essential for infective hepatitis and for severe and chronic cases. The treatments may be continued as long as clinically indicated.
OVERDOSAGE AND TREATMENT:
No particular antidote is available for the treatment of Overdose. The signs and symptoms should be treated symptomatically.
Price of silybon 70/140 in Nigeria
In Nigeria, a pack of silybon containing 30 tablets is sold for #3,000 naira ($6). Many big pharmacies in Abuja, Lagos, Port Harcourt, Kaduna, Benin city and other parts of the country.
STORAGE:
store below 25°C. Keep out from the reach of children.
PRESENTATION:
30°’s Blister pack.
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