List of Drugs that causes erectile dysfunction (Weak Erection), list the drugs that are associated with erectile dysfunction, what blood pressure medication does not cause erectile dysfunction?

The symptoms of erectile dysfunction include: inability to achieve/sustain an erection, weak erection, premature ejaculation, low sex drive (libido) and low testosterone levels.

Yes, most of our everyday drugs and over-counter- drugs can cause erectile dysfunction, impotence or weak erection. It is important you know these drugs so you can have an informed discussion with your doctor and other health care providers.

List of Drugs that causes erectile dysfunction (Weak Erection)

Below are classes of the drugs

  • Diuretics e.g thiazides, frusemide
  • Antihypertensives
  • Antihistamines
  • Opiates
  • Antidepressants
  • Parkinson’s disease drugs
  • Antiarrhythmics e.g. disopyramide(Norpace)
  • Tranquilizers
  • Muscle relaxants
  • Non-steroidal anti-inflammatory drugs
  • Histamine H2-receptor antagonists
  • Hormones
  • Chemotherapy medications
  • Prostate cancer drugs
  • Anti-seizure medications
  • Recreational drugs

Breaking it down further in order to list individual drug implicated in causing weak erection below..

Opiate analgesics (painkillers)- opiods:

  • Codeine
  • Fentanyl (Innovar)
  • Hydromorphone (Dilaudid)
  • Meperidine (Demerol)
  • Methadone
  • Morphine
  • Oxycodone (Oxycontin, Percodan)

Antidepressants and other psychiatric medicines:

  • Amitriptyline (Elavil)
  • Amoxapine (Asendin)
  • Buspirone (Buspar)
  • Chlordiazepoxide (Librium)
  • Chlorpromazine (Thorazine)
  • Clomipramine (Anafranil)
  • Clorazepate (Tranxene)
  • Desipramine (Norpramin)
  • Diazepam (Valium)
  • Doxepin (Sinequan)
  • Fluoxetine (Prozac)
  • Fluphenazine (Prolixin)
  • Imipramine (Tofranil)
  • Isocarboxazid (Marplan)
  • Lorazepam (Ativan)
  • Meprobamate (Equanil)
  • Mesoridazine (Serentil)
  • Nortriptyline (Pamelor)
  • Oxazepam (Serax)
  • Phenelzine (Nardil)
  • Phenytoin (Dilantin)
  • Sertraline (Zoloft)
  • Thioridazine (Mellaril)
  • Thiothixene (Navane)
  • Tranylcypromine (Parnate)
  • Trifluoperazine (Stelazine)

Antihistamine medicines (certain classes of antihistamines are also used to treat heartburn itching and nasal congestion):

  • Cimetidine (Tagamet)
  • Dimenhydrinate (Dramamine)
  • Diphenhydramine (Benadryl)
  • Hydroxyzine (Vistaril)
  • Meclizine (Antivert)
  • Nizatidine (Axid)
  • Promethazine (Phenergan)
  • Ranitidine (Zantac)

High blood pressure medicines and diuretics (water pills):

  • Atenolol (Tenormin)
  • Bethanidine
  • Bumetanide (Bumex)
  • Captopril (Capoten)- ACEI
  • Chlorothiazide (Diuril)
  • Chlorthalidone (Hygroton)
  • Clonidine (Catapres)
  • Enalapril (Vasotec)
  • Furosemide (Lasix)
  • Guanabenz (Wytensin)
  • Guanethidine (Ismelin)
  • Guanfacine (Tenex)
  • Amlodipine (rarely)
  • Haloperidol (Haldol)
  • Hydralazine (Apresoline)
  • Hydrochlorothiazide (Esidrix)
  • Labetalol (Normodyne)
  • Methyldopa (Aldomet)
  • Metoprolol (Lopressor)
  • Nifedipine (Adalat, Procardia)
  • Phenoxybenzamine (Dibenzyline)
  • Phentolamine (Regitine)
  • Prazosin (Minipress)
  • Propranolol (Inderal) – common
  • Reserpine (Serpasil)
  • Spironolactone (Aldactone)
  • Triamterene (Maxzide)
  • Verapamil (Calan)

Recreational drugs:

  • Amphetamines
  • Barbiturates
  • Cocaine
  • Marijuana
  • Heroin
  • Nicotine
  • Alcohol

Anti-Parkisonism Drugs:

  • Biperiden(Akineton)
  • Benztropine(Cogentin)
  • Trihexyphenidyl(Artane)
  • Procyclidine(Kemadrin)
  • Bromocriptine(Parlodel)
  • Levodopa (Sinemet)

Chemotherapy drugs:

  • Busulfan (Myleran)
  • Cyclophosphamide(Cytoxan)
  • Methothrexate
  • Ketoconazole
  • Paclitaxel
  • Tamoxefin

Prostate cancer drugs:

  • Flutamide (Eulexin)
  • Leuprolide (Lupron)

Muscle relaxants:

  • Cyclobenzaprine(Flexeril)
  • Orphenadrine(Norflex)

Non-steroidal Anti-inflammatory Drugs(NSAIDs)

  • Naproxen
  • Indomethacin
  • Ibuprofen
  • Diclofenac

Recreational drugs

  • Alcohol
  • Amphetamines
  • Barbiturates
  • Cocaine
  • Marijuana
  • Methadone
  • Nicotine
  • Opiates

Anti-seizure drugs/anti-epileptic drugs

These drugs are reputed to reduce testosterone levels and cause weak erection or low libido

  • phenobarbital
  • phenytoin
  • carbamazepine (tegretol)
  • primidone
  • oxcarbazepine
  • Sodium vaproate (epilim) decreases sperm count
  • Depakote
  • Levetiracetam (keppra)

Proton pump inhibitors

  • omeprazole,
  • pantoprazole,
  • esomeprazole (nexium)

Other medicines:

  • Aminocaproic acid (Amicar)
  • Atropine
  • Clofibrate (Atromid-S)
  • Cyclobenzaprine (Flexeril)
  • Cyproterone
  • Digoxin (Lanoxin)
  • Disopyramide (Norpace)
  • Estrogen
  • Finasteride (Propecia, Proscar, Avodart)
  • Furazolidone (Furoxone)
  • H2 blockers (Tagamet, Zantac, Pepcid)
  • Licorice
  • Metoclopramide (Reglan or Maxolon)
  • Orphenadrine (Norflex)
  • Prochlorperazine (Compazine)
  • Pseudoephedrine (Sudafed)
  • Sumatriptan (Imitrex)
  • Sirdalaud
  • sulfasalazine
  • Spironolactone


1. Lipid lowering agents like statins do NOT cause erectile dysfunction

2. Amlodipine rarely cause erectile dysfunction

3. Losartan does NOT cause ED, it even improves sexual function.

3. ARBs such as losartan, valsartan, and irbesartan have shown a beneficial effect on erectile function.

4. Omeprazole is notorious for causing erectile dysfuction (impotence) because it reduces testosterone levels and impairs the penis vascular redox biology. The research fimdingd on whether this side effect is reversible is controversial and yet to be concluded. Most studies i read reported it to be reversible and 3-6weeks but gradually. This side effect is same for other proton pump inhibitors but worse for omeprazole.

5. ACE (angiotensin converting enzyme) inhibitors — such as Captopril (Capoten), Benazepril(Lotensin), and Lisinopril (Prinivil or Zestril) widen blood vessels and increase blood flow to the penis. Hypertensive patients on these drugs that complain of erectile dysfunction are less than 1 percent. Weak erection or impotence is rarely a side effect.

6. High blood pressure medications that are not likely to cause erectile dysfunction (impotence) are: ACE inhibitors, Alpha – blockers, calcium channel blockers and angiotensin receptor blockers (ARBs).

Caveat: This article is for your information and enlightenment, it is not a substitute to discussing with your doctor or even seeing a doctor.

List of Drugs that causes erectile dysfunction
List of Drugs that causes erectile dysfunction
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Credit: Wikipedia







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