Neuracalm 75 mg: composition, Uses, dosages, side effects, & Price
Composition of Neuracalm;
Pregabalin (75 mg) & Methylcobalamin (750 mcg) Capsules.
THE DESCRIPTION OF THE DRUG:
Brand Name: NEURACALM- 75
Generic Name:PREGABALIN ( 75 MG) & METHYLCOBALAMIN (750 MCG) CAPSULES
Dosage Form And Strenght: Solid Oral Dosage Form; Capsule 75mg/750mcg
Active Ingredients in Neuracalm 75:
👉Pregabalin: C8 H17 NO2
👉Methylcobalamin: C63 H91 CoN13 O14P
Net Content: 75 mg/750 mcg
CLINICAL PHARMACOLOGY:
Mechanism Of Action:
Pregabalin is an oral medication that is chemically related to gabapentin (Neurontin, Gabarone). It is used for treating pain caused by neurologic diseases such as postherpetic neuralgia as well as seizures. It also is used for treating fibromyalgia. The mechanism of action of pregabalin is unknown.
Pregabalin binds to calcium channels on nerves and may modify the release of neurotransmitters (chemicals that nerves use to communicate with each other). Reducing communication between nerves may contribute to pregabalin’s effect on pain and seizures.
Methylcobalamine: Vitamin B12 normally plays a significant role in the metabolism of every cell of the body, especially affecting the DNA synthesis and regulation but also fatty acid synthesis and energy production.
However, many (though not all) of the effects of functions of B12 can be replaced by sufficient quantities of folic acid (vitamin B9), since B12 is used to regenerate folate in the body.
Most vitamin B12 deficiency symptoms are actually folate deficiency symptoms, since they include all the effects of pernicious anemia and megaloblastosis, which are due to poor synthesis of DNA when the body does not have a proper supply of folic acid for the production of thymine.
When sufficient folic acid is available, all known B12 related deficiency syndromes normalize, save those narrowly connected with the vitamin B12-dependent enzymes Methylmalonyl Coenzyme Amutase, and 5-methyltetrahydrofolate-homocysteine methyltransferase (MTR), also known as methionine synthase; and the buildup of their respective substrates (methylmalonic acid, MMA) and homocysteine.
Pharmacokinetics And Metabolism:
Pregabalin: Absorption: Pregabalin is rapidly absorbed when administered on an empty stomach, with peak plasma concentrations occuring within one hour. Pregabalin oral bioavailability is estimated to be greater than or equal to 90% and is independent of dose.
The rate of pregabalin absorption is decreased when given with food resulting in a decrease in Cmax by approximately 25 to 30% and a delay Tmax to approximately 2.5 hours. Administration with food, however, has no clinically significant effect on the extent of absorption.
Distribution:
Pregabalin has been shown to cross the blood-brain barrier in nice, rats, and monkeys. Pregabalin has been shown to cross the placenta in rats and is present in the milk of lactating rats.
In humans, the volume of distribution of pregabalin for an orally administered dose is approximately 0.56 L/kg and is not bound to plasma proteins.
Metabolism:
Pregabalin undergoes negligible metabolism in humans. Approximately 98% of the radioactivity recovered in the urine was unchanged pregabalin. The major metabolite is N-methyl pregabalin.
Excretion:
Pregabalin is eliminated from the systemic circulation primarily by renal excretion as unchanged drug. Renal clearance of pregabalin is 73 mL/minute.
Methylcobalamine:
Methylcobalamin as adenosylcobalamin and hydroxocobalamin. These act as co-enzymes in the trans methylation of homocysteine to methionine; in the isomerisation of Methylmalonyl co-enzyme to succinyl co-enzyme and with folate in several metabolic pathways respectively. Deficiency of Vitamin B12 interferes with haemopoiesis and produces megaloblastic anaemia.
INDICATIONS AND USES OF NEURACALM 75:
👉Possesses anxiolytic, analgesic and anticonvulsant activity.
👉Possess high bioavailability (90% vs 33-66%) compared to pregabalin.
👉Highly effective in relieving the neuropathic pain.
👉Improves mood and reduces sleep disturbance.
👉Acts as neuroprotective, promotes myelination in neurons.
👉Relieves burning sensation, numbness, loss of sensation and muscle cramps in diabetic neuropathy.
. Peripheral Neuropathy.
. Diabetic Neuropathy.
. Drug Induced Neuropathy.
CONTRAINDICATIONS TO NEURACALM:
Hypersensitivity, pregnancy, lactation. Driving or working with machines, or do other dangerous activities.
DRUG INTERACTIONS:
Concurrent use with oxycodone, lorazepam and ethanol may increase the CNS effects of neuracalm.
WARNINGS:
. May cause peripheral oedema.
. Regular vision check is recommended.
. May decrease platelet count and prolong PR interval.
PRECAUTIONS:
. Discontinue treatment if patients develop severe angioedema.
. Withdraw treatment gradually over at least 1 week.
ADVERSE REACTIONS AND SIDE EFFECTS OF NEURACALM 75:
Dizziness, drowsiness, visual disturbance (including blurred vision, diplopia), ataxia, dysarthria, tremor, lethargy, memory impairment, euphoria, weight gain, constipation, dry mouth, peripheral edema, depression, confusion, agitation, hallucinations, myoclonus, hypoaeshesia, hyperaesthesia, tachycardia, excessive salivation, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, neutropenia, 1st degree heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis.
DRUG ABUSE AND DEPENDANCE:Not Applicable
SYMPTOMS OF OVERDOSE AND ANTIDOTE:
Pregabalin: In overdose up to 15 g, no unexpected adverse reactions were reported. In the post-marketing experience, the most commonly reported adverse reactions observed when pregabalin was taken in overdose included somnolence, confusional state, agitation, and restlessness.
Treatment of pregabalin overdose should include general supportive measures and may include haemodialysis if necessary.
Methylcobalamine:Most nutrients have an established tolerable upper intake level, helping you identify the maximum amount you can safely consume.
Since methylcobalamine is generally safe, even at high doses, there is no upper limit set for the vitamin.
DOSAGE AND ADMINISTRATION:
One capsule two or three times daily or as directed by physician. I normally prescribed neuracalm 75mg as one capsule three times daily to diabetic patients patients with severe diabetic neuropathy.
PRICE
The cost is of a pack of of neuracalm 75 containing 3 satchets of 10 capsules is #4,500 naira in many big pharmacies.
PRESENTATION:
A pack of neuracalm 75mg contains3 satchets. Each satchet contains 10 capsules.
STORAGE CONDITION:
Store in a dry place at a temperature below 30°c.
This article is the intellectual property of www.nimedhealth.com.ng
