IV ASTYMIN SN INFUSION: Uses, Benefits, Indications, contraindications, Ingredients, Composition, Dosage, Side Effects & Price
ASTYMIN -SN (PURE CRYSTALLINE AMINO ACIDS I. V. INFUSION WITH XYLITOL)
ASTYMIN_SN contains all ESSENTIAL AMINO ACIDS & NON_ESSENTIAL AMINO ACIDS with xylitol. Astymin _SN is a total amino acids infusion formulated as per WHO/FAO recommendations. The composition is also in accordance with VUJ-N mixture and human plasma serum concentration. With the addiction of insulin independent xylitol, Astymin -SN delivers protein sparing effect.
Astymin -SN increases protein synthesis, improves nutritional status and builds body resistance. In conditions of HIGH NITROGEN & PROTEIN NEEDS, Astymin -SN is an ideal formula.
INGREDIENTS AND COMPOSITION OF ASTYMIN INFUSION:
Each ml. contains :
L- Isoleucine USP 5.6mg
L- Leucine USP 12.5mg
L- Lysine Hydrochloride USP 11mg
L- methionine USP 3.5mg
L- phenylalanine USP 9.35mg
L- Threonine USP 6.5mg
L- Tryptophan USP 1.3mg
L -Valine USP 4.5mg
L- Alanine USP 6.2mg
L- Arginine Hydrochloride USP 9.55mg
L- Aspartic Acid BP 3.8mg
L- Cysteine Hydrochloride USP 1.45mg
L- Glutamic Acid USSRP 6.5mg
L- Histidine Hydrochloride H2O BP 8.11mg
L- Proline USP 3.3 mg
L- Serine USP 2.2mg
L- Tyrosine USP 0.35mg
Glycine USP 10.7mg
Xylitol USP 50mg
Water for injections BP q.s.
Contents per 200ml
Total Amino acids 21.282 gm
Total Essential amino acids 10.850 gm
Total Non Essential Amino acids 10.432 gm
Total Branched Chain Amino acids 22.6 %
Total Nitrogen content 3.04 gm
High Biological Value protein content 19.0 gm
E/N Ratio 1
Energy content 135 cal
USES, FUNCTIONS BENEFITS AND INDICATIONS FOR ASTYMIN INFUSION :
👉Persistent pyrexial states
👉Malabsorption in G. I. disorders
👉Pre & post operative conditions
💔Fracture of long bones
DOSAGE & ADMINISTRATION :
👉Adults : 200- 800 ml l. V. /day
👉Children : 0.2 – 0.25 gm of Nitrogen /kg body weight
👉IV Astymin dosage in pregnancy: 200ml daily for a duration to be determined by your doctor.
👉Drop Rate : 15- 20 Drops initially, followed by 30- 40 Drops per minute
WARNING : Not to be use if any suspended matter is present
RECOMMENDED ENERGY REQUIREMENTS :
Recommended simultaneous calorie supply is 150-200 cal. /gm of Nitrogen
CLINICAL PHARMACOLOGY :
Astymin SN provides a physiological ratio of biologically utilizable essential and non essential amino acids with xylitol to meet adult requirements. The amino acids provide a substrate for protein synthesis as well as sparing body protein and muscle mass.
Peripheral intravenous infusions of amino acids administered for short periods in selected patients promote protein anabolism and prevent protein breakdown to meet caloric requirements.
INTERACTION OF ASTYMIN :
Astymin-SN IV infusion should not be administered along with mannitol. Mannitol being an osmotic diuretic, the amino acid infused will be rapidly excreted from the body.
ASTYMIN INFUSION SIDE EFFECTS :
Local reactions consisting of erythema, phlebitis and thrombosis at the infusion site have occurred with peripheral intravenous infusion of amino acids particularly of other substances, such as antibiotics, are also administered through the same site. In such cases the infusion site should be changed promptly to another vein. Use of large peripheral veins, inline filters, and slowing the rate of infusion may reduce the incidence of local venous irritation.
Electrolyte additives should be spread throughout the day. Irritating additive medications may need to be injected at another venous site.
Generalized flushing. Fever and nausea also have been reported during peripheral infusions of amino acid infusion solutions.
SYMPTOMS & OVERDOSAGE:
If Astymin-SN IV Infusion is administered at a higher rate than recommended, there is an augmented risk for nausea, vomiting and sweating. When peripheral veins are used thrombophlebitis may occur.Osmotic diuresis with dehydration may occur if the dosage recommendations are exceeded.
There is also a risk of symptoms related to hyperglycemia with Astymin SN IV Infusion. In case of symptoms due to overdose, the infusion should be slowed down or discontinued.
PREGNANCY & LACTATION:
Animal reproduction studies or clinical investigations during pregnancy have not been carried out with Astymin -SN IV Infusion.
However, there are published reports of successful and safe administration of amino acid solutions during pregnancy.
Hypersensitivity to amino acids, cardiac insufficiency, irreversible liver damage.
Astymin-SN IV Infusion should be used with caution in patients with diabetes mellitus, severe heart failure or with renal function in combination with fluid restrictions or oliguria /anuria of other origin.
In patient with hyperglycemia, administration of exogenous insulin might be necessary. Feeding of carbohydrates in severely malnourished patients can trigger a thiamine (vitamin B1) deficiency syndrome.
The drip rate initially should be 15 to 20 drops per minute, followed by 30 to 40 drops per minute. Signs of intolerance and increased renal losses resulting in amino acid disequilibrium are possible if infusion rate is too rapid.
Keep all medicines out of the reach from children
Infusion bottle of 200ml. With individual carton.
PRICE OF ASTYMIN INFUSION
A bottle of 200ML Astymin infusion is sold for #5, 000 Naira which is equivalent to about $8 dollars.
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